Titan Spine Announces New Memphis Distribution Center to Meet Growing Demand for nanoLOCK® Spinal Implants

MEQUON, Wis., March 26, 2018 – Titan Spine, a medical device surface technology company focused on developing innovative spinal interbody fusion implants, today announced it has opened a distribution facility in Memphis to meet the growing demand for the Company’s nanoLOCK® surface technology. nanoLOCK® is the company’s next-generation surface technology featuring enhanced micro and nano-scaled architecture, proven to significantly improve the osteogenic response it creates.1

The new distribution facility increases Titan Spine’s capacity to more than 20,000 square feet and will be used to efficiently distribute nanoLOCK® as well as products from future launches. In addition, the facility is strategically located within close proximity to the FedEx world distribution hub, which allows Titan Spine to extend shipment hours when needed and enable agility in responding to customer needs.

Mark Berg, Executive Vice President Global Operations of Titan Spine, commented, “As the demand for our nanoLOCK® surface implants has continued to grow across the U.S., we recognized the need to strategically increase our distribution capacity to supply current and future demand. Our Memphis Distribution Center (MDC) offers an optimal solution that builds upon the efforts of our prior distribution partner. We are excited to further improving logistics for our surgeon and distributor customers who recognize the significance and uniqueness of nanoLOCK® ’s very specific ability to promote a nano-fusion.”

Titan Spine offers a full line of Endoskeleton® titanium implants that feature its proprietary nanoLOCK® surface technology, which was launched in the U.S. in October 2016 following FDA clearance in late 2014. The nanoLOCK® surface technology consists of a unique combination of roughened topographies at the macro, micro, and nano levels (MMN™). This unique combination of surface topographies is designed to create an optimal host-bone response and actively participate in the fusion process by promoting the upregulation of osteogenic and angiogenic factors necessary for bone growth, encouraging natural production of bone morphogenetic proteins (BMPs), downregulating inflammatory factors, and creating the potential for a faster and more robust fusion.2,3,4 All Endoskeleton® devices are covered by the company’s risk share warranty

About Titan Spine

Titan Spine, LLC is a surface technology company focused on the design and manufacture of interbody fusion devices for the spine. The company is committed to advancing the science of surface engineering to enhance the treatment of various pathologies of the spine that require fusion. Titan Spine, located in Mequon, Wisconsin and Laichingen, Germany, markets a full line of Endoskeleton® interbody devices featuring its proprietary textured surface in the U.S., portions of Europe, and Australia through its sales force and a network of independent distributors. To learn more, visit www.titanspine.com

1Olivares-Navarrete, R., Hyzy S.L., Gittens, R.A., Berg, M.E., Schneider, J.M., Hotchkiss, K., Schwartz, Z., Boyan, B. D. Osteoblast lineage cells can discriminate microscale topographic features on titanium-aluminum-vanadium surfaces. Ann Biomed Eng. 2014 Dec; 42 (12): 2551-61.

2Olivares-Navarrete, R., Hyzy, S.L., Slosar, P.J., Schneider, J.M., Schwartz, Z., and Boyan, B.D. (2015). Implant materials generate different peri-implant inflammatory factors: PEEK promotes fibrosis and micro-textured titanium promotes osteogenic factors.  Spine, Volume 40, Issue 6, 399–404.

3Olivares-Navarrete, R., Gittens, R.A., Schneider, J.M., Hyzy, S.L., Haithcock, D.A., Ullrich, P.F., Schwartz, Z., Boyan, B.D.  (2012). Osteoblasts exhibit a more differentiated phenotype and increased bone morphogenetic production on titanium alloy substrates than poly-ether-ether-ketone.  The Spine Journal, 12, 265-272.

4Olivares-Navarrete, R., Hyzy, S.L., Gittens, R.A., Schneider, J.M., Haithcock, D.A., Ullrich, P.F., Slosar, P. J., Schwartz, Z., Boyan, B.D.  (2013). Rough titanium alloys regulate osteoblast production of angiogenic factors.  The Spine Journal, 13, 1563-1570.