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nanoLOCK® SURFACE TECHNOLOGY

What is nanoLOCK® Surface Technology?

Shortly after launching our original surface in 2007 and witnessing how well patients were responding to our technology, we challenged ourselves to make it even better. We began working with some of the brightest minds in biomaterial sciences to investigate ways to improve the bone formation response to our implants. The result? nanoLOCK® surface technology, which has been proven to upregulate a significantly greater amount of bone growth factors than even our original surface.1

How did we do that? By incorporating a significantly greater amount of the microscopic and nanoscopic features that are found on natural bone.2 That means the body “sees” the implant surface as being conducive to bone growth and begins the process virtually from the moment the device is implanted.3

nanoLOCK® is the first and only FDA-cleared nanotechnology device for the spine. And it is the only technology with access to the CMS new technology code for nanotextured interbody devices. It is the recipient of several awards, including the prestigious Whitecloud Award for best basic science, and has been used as an example of commercialized nanotechnology success in medicine by the White House Office of Science and Technology as part of the National Nanotechnology Initiative. nanoLOCK® has been published in five peer-reviewed publications and was commercially launched in August of 2016.

Oh, and did we mention that it is guaranteed to fuse?

  1. Oltvares-Navarrete, R., Hyzy S.L., Gittens, R.A., Berg, M.E., Schneider, J.M., Hotchkiss, K., Schwartz, Z., Boyan, B. D. Osteoblast lineage cells can discriminate microscale topographic features on titanium-aluminum-vanadium surfaces. Ann Biomed Eng. 2014 Dec; 42 (12): 2551-61.
  2. Matteson JL, Greenspan DC, Tighe TB, et al. Assessing the hierarchical structure of titanium implant surfaces. Journal of Biomedical Materials Research Part B Applied Biomaterials 104(6). May 2015. DOI:10.1002/jbm.b.33462.
  3. Data on file.

Early Stages of Bone Growth

The following is a depiction of the early stages of bone growth following implantation of the nanoLOCK® surface based on extensive research. The rapid bone growth response seen here would not occur on surfaces with different material composition or micro/nano architecture.

DAY 1 Fibrin blood clot formation between the implant and bone bed.
DAY 3 Early stages of bone growth and vascularization featuring the migration of mesenchymal stem cells through the clot and early differentiation into bone forming cells called osteoblasts.
DAYS 14-21 Robust primary bidirectional woven bone formation due to the activity and signaling of the osteoblasts.
DAY 21 Formation of mature bone as the osteoblasts transition into mature bone cells called osteocytes.

Textured Surface Impacts the Fusion Process

nanoLOCK® participates in the fusion process through a proprietary combination of textures at the macro, micro, and nano (MMNTM) levels.

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Bone Growth Begins in 24 Hours, Not 24 Days

Human stem cell showing signs of differentiation into a bone-forming osteoblast cell at 24 hours on the nanoLOCK® surface.

Leveraging Nature’s Expertise

Biomimicry is an approach to innovation that leverages nature’s time-tested expertise to solve complex human challenges. We looked to nature to aid in the design of nanoLOCK®.

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Press Releases

Chad Kolean Named CFO

Chad Kolean Named CFO

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Ed Graubart Named VP of Professional Development

Ed Graubart Named VP of Professional Development

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Titan Spine® Announces Review of Research Supporting its nanoLOCK® Titanium Spinal Implants Published in SPINE

Titan Spine® Announces Review of Research Supporting its nanoLOCK® Titanium Spinal Implants Published in SPINE

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Titan Spine Announces New Memphis Distribution Center to Meet Growing Demand for nanoLOCK® Spinal Implants

Titan Spine Announces New Memphis Distribution Center to Meet Growing Demand for nanoLOCK® Spinal Implants

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Titan Spine Announces the First Endoskeleton® Interbody Fusion Cases in Australia

Titan Spine Announces the First Endoskeleton® Interbody Fusion Cases in Australia

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